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Phase I clinical trials are the first-in-human studies when a drug is given to a small group of healthy or diseased voluntee

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The authors of this Review describe the current first-line treatment options for EGFR-mutant NSCLC, discuss mechanisms of acquired resistance to third-generation EGFR TKIs and new promising treatment strategies, such as bispecific antibodies, next-generation TKIs, antibodydrug conjugates, immunotherapy approaches and targeted protein degraders.

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