metabolite s-gamma-glu-cys precursor glutathione The pathway in Saccharomyces cerevisiae. The synthesis of Cysteine metabolic circuitries: druggable targets

Environ Health Prev Med 8:161165

Glutathione contributes to various biological processes, including: Immune function Protection against oxidative stress Detoxification When the amount of oxidative stress is high, the naturally-occurring glutathione may not be sufficient

Whereas, the enzyme localized in cytosol shows glutathione peroxidase activity, its lysosomal counterpart performs calcium independent phospholipase A2 (aiPLA2) activity

Thus, hemolysis, hemorrhage, or erythropoietic effects predispose to ferroptosis

mPFC CCK knockdown in KI mice ameliorates susceptibility to SDS-induced anxiety The hypersecretion of CCK in the mPFC during SDS in adult KI mice may arise not only from heightened local Cck expression but also potentially from afferent inputs originating in other brain regions

[118], studied the use of IN OT as a treatment for Anorexia Nervosa (AN), an illness marked by high anxiety, social behavior deficit, and withdrawal, because evidence suggests that OT can improve this condition [119,120,121]