glutathione oxidation reduction cycle Cellular redox of reduced and oxidized Glutathione. It summarizes Untitled Document

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10.1172/jci.insight.168440 27 ChoiE

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A landmark clinical trial published in 2010 demonstrated that H-enriched dialysis fluid reduced oxidative stress markers in patients undergoing hemodialysis.7 Subsequent research explored various administration methodssuch as inhalation, H-rich drinking water, H-generating nanomaterials, and H-releasing solid-state compoundsacross diverse experimental and clinical settings.8,9 Additionally, investigations have consistently confirmed that H selectively targets harmful radicals, reduces inflammation, and beneficially modulates cellular signaling pathways implicated in cardiovascular, neurodegenerative, and renal disorders.10,11 Recent studies have observed the beneficial role of H in renal disorders through mechanisms involving redox modulation and inflammatory response regulation.8,9,12,13,14,15 A recent review observed H as a potential intervention in CKD, highlighting its modulation of oxidative stress-related pathways including: (i) the nuclear factor erythroid 2-related factor 2Kelch-like ECH-associated protein 1 complex (Nrf2Keap1)