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For lymphoma formation in particular, activating the lymphocyte-macrophage axissuch as the one observed in active sarcoidosisis a primary driver of malignant proliferation [4,10]

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In addition, their extended (and probably unmyelinated) axon, and the number of striatal synapses established are characteristics expected to exert a high energy demand on the maintenance of plasma membrane potential (ionic gradients), protein/organelle (mitochondria) traffic and homeostasis [218, 253, 262]

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