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Description

Metabolites 2:516528

However, unlike previous findings, shikonin, icariin, and other drugs induce mitochondrial dysfunction by increasing ROS levels, decreasing mitochondrial membrane potential, and elevating the release of cytochrome C and pro-apoptotic proteins, such as caspase-3 and caspase-9, to induce apoptosis in FLSs to suppress inflammatory response (265, 266)

Its structure is exceptionally simple: just four amino acids joined in a chain

[DOI] [PubMed] [Google Scholar] 458.Zhongyin Z, Wei W, Juan X, Guohua F

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