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(C) This graphical representation demonstrates the pattern of T4 mRNA and protein levels between the dorsal skin samples of the three groups obtained from real-time PCR and western blotting analysis

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Conversely, at higher concentrations (5-10 M) or in melanocytes with elevated baseline melanogenic activity, GHK-Cu can suppress tyrosinase activity and reduce melanin production by 20-40%, offering potential benefits in melasma or post-inflammatory hyperpigmentation

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The results show that hyperalgesia (increased mechanosensitivity and thermosensitivity) was induced from 3 to 7 weeks after methylmercury exposure, followed by hypoalgesia (decreased mechanosensitivity and thermosensitivity) from 13 to 15 weeks after exposure