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In the process, he discovered that ingesting large amounts of liver seemed to most-rapidly cure the anemia of blood loss, and hypothesized that therefore liver ingestion be tried for pernicious anemia, an anemic disease of the time with no known cause or cure

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Methylcobalamin and adenosylcobalamin represent the two active forms that participate directly in cellular metabolism

One of the possible reasons that anaemia is much less prominent in B12 deficiency than lets say 30 years ago, is that many countries have started mandatory fortification of food with folate

This includes people who dont get enough sun, older people whose bodies are unable to produce as much Vitamin D, and people with darker complexions, whose skin is more resistant to the suns UV rays

While these findings dont prove cause and effect, they hint that enough vitamin D is key for managing pain