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Patients with atrial arrhythmias (atrial flutter or atrial fibrillation) and pulmonary hypertension do not tolerate the loss of the atrial kick well as it contributes a significant amount to their RV filling and impacts their cardiac output

It may contribute to a more youthful physiological state, extending longevity and lowering the risk of age-related disorders, by perhaps slowing cellular senescence, or the aging of cells

PMID 26288227

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Again what we saw was Sistine went up, so it was not working really, it was getting broken down

It is a powerful glycemic stabilizer that increases insulin levels and decreases glucagon secretion, which helps stabilize blood sugar levels