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While the chronic ethanol ingestion period of the present experiment was shorter (47 days) than that of experiment 1, the rats showed a marked relapse intake to ethanol after two weeks of deprivation (alcohol reaccess on day 62), likely due to neuroinflammation and oxidative stress that self-perpetuate each other after ethanol is discontinued (see Israel et al., On the last 4 days of the 14-day ethanol deprivation period, rats were divided into five groups ( n = 6 rats/group): (1) LY341495/NAC group: rats were given LY341495, an inhibitor of the mGlu2/3 receptor, at a dose of 1 mg/kg per day (i.p.), 15 min before NAC administration (100 mg/kg per day by oral gavage (Fukumoto et al., via i.p

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