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65 Despite efforts have been made to repair mtDNA with various mechanisms, the mutation rate of mtDNA remains higher than nuclear DNA

Hecht SS, C-hB C, Ohmori T et al (1980) Comparative Carcinogenicity in F344 Rats of the Tobacco-specific Nitrosamines, N-Nitrosonornicotine and 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone1

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doi: 10.1038/srep26241

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