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It is worth mentioning that ebselen does not contribute to the bioavailable selenium pool required for the biosynthesis of selenoproteins including seleno-GPxs and therefore its ability to detoxify hydroperoxides under cellular conditions can exclusively be attributed to GPx mimicking activity [77, 79]

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38 Tested on heme proteins, it showed reliable shifts (0.85 correlation) and matched experimental data, aiding in the understating on ROS biology by advancing the prediction and engineering of redox-active proteins and understanding redox signaling in cellular processes and diseases