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Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2) Oncogene

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H 2 S could perform a nucleophilic attack on oxidized protein cysteine residues either as sulfenic acid, disulfide bond or glutathione adducts ( 2 S, the resulting persulfide being reduced by Trx ( 2 S is a poor reductant compared to glutathione and that it is also less abundant and reactive