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(2019) Mechanisms of ferroptosis and relations with regulated cell death: A review, Front Physiol

ALA, PBG and uroporphyrin are largely excreted in the urine while coproporphyrin is preferentially and protoporphyrin exclusively excreted in the bile and feces

Specifically, in GLO2-deficient cells, D-Kla modification of phosphoglycerate dehydrogenase, the first and rate-limiting enzyme in de novo serine biosynthesis, leads to the inhibition of its enzymatic activity, thereby resulting in reduced intracellular levels of serine [43]

PCa is one of the most prevalent malignancies affecting men, 46 and recent research has unveiled the noteworthy role of TQ, a prominent bioactive compound in Nigella sativa , in influencing PCa markers ( Table 2)

A study confirmed that the expression levels of MT genes were higher in people with overweight than those of Zn transporters (ZnT-1, Zip-1, and Zip-3) [35]

All data generated or analyzed during this study are available with this work