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J.HealyD.et al (2021)

In previous studies, the connection between effort-based motivated performance in humans and levels of various metabolites in the accumbal region, was measured using 1 H-MRS at 7 Tesla before performing a physical effort-based motivated task (MIFT) (16, 17)

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Much of the purported clinical utility is derived from anecdotal accounts or small, uncontrolled series, rather than from robust randomized trials