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Reviews that focus on phytochemicals emphasize mechanisms and preclinical efficacy, while nanoparticle reviews cover transport strategies and materials science, and few syntheses explicitly integrate nano-design variables with BBB transport outcomes for phytochemicals (26, 27)

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The canonical SMILES CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)O)N encodes the L-configured Ala-Glu-Asp-Gly backbone with three amide bonds linking the four residues

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These findings have contributed to growing scientific interest in NNMT as a target for metabolic research