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Therefore, clinical vigilance and readily available investigation algorithms are helpful

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[228] Based upon preclinical research, cerebral carbonic anhydrase activation has cognition-enhancing effects

A 2017 systematic review and meta-analysis identified 12 intervention studies that assessed the effect of L-carnitine or ALCAR on cancer-related fatigue (reported as a primary or secondary outcome) in cancer survivors (108)

Addressing these dimensions will be essential for further understanding whether SLC25A45-dependent carnitine metabolism represents a universal adaptive mechanism or one selectively engaged under specific physiological or pathological conditions