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Common Side Effects Water retention & flushing: Mild water retention, headaches or transient flushing can occur

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NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

However, it can have diverse clinical manifestations ranging from asymptomatic to severe neurological and hematological abnormalities that lead to death if untreated [2]

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