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In contrast, when PKM2 exists in its monomeric or dimeric form, it can enter the nucleus and function as a coactivator for several transcription factors (such as HIF-1, -catenin/c-Myc, NF-B, and STAT3), regulating metabolic reprogramming and gene expression to meet various physiological demands [49]
An intronic promoter controls the expression of truncated human -glutamyltransferase mRNAs
Methylglyoxal reductase catalyzes the reduction of 2-oxoaldehydes to the corresponding 2-hydroxyaldehydes and then converts aldehydes to alcohol 40
Some patients exhibit spinocerebellar degeneration, peripheral neuropathy, myopathy, and aminoaciduria (Njalsson and Norgren, 2005
