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doi: 10.1111/jdi.13725 8 MaTLiXZhuYYuSLiuTZhangXet al

For either compound to move from no toxicity demonstrated to safety established for a defined use, the following would ordinarily be required and none of it is presently complete in the public record for these substances as sold: GLP-compliant repeated-dose toxicity of adequate duration typically up to chronic (6- to 12-month) studies in a rodent and a non-rodent species, with full clinical pathology and histopathology, to detect cumulative organ effects