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In the microenvironments of breast cancer and pancreatic cancer, the expression of the key glycolytic enzymes PKM2 and LDHA in CAFs is increased [324, 325]

However, symptoms dont occur every day

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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Sahlin K

This interaction is particularly relevant in patients at risk for folate deficiency, such as those with malabsorption disorders, chronic alcohol use, or those taking medications that interfere with folate metabolism
