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Nicotinamide adenine dinucleotide (NAD+) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases

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Supplementation of one of these compounds, -tocopherol, attacks free radicals to prevent lipid oxidation in retina and other body tissues.7,8