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The day after LPS administration, all mice in each group were evaluated behaviorally using an open-field test (OFT), an immobility test using a tail-suspension test (TST), and a forced swim test (FST)

doi: 10.1172/JCI20945

Importantly, NRF2 regulates the expression of drug transporters and downregulation of NRF2 inhibits the expression of drug transporters and blocks chemoresistance

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As a member of the Sirtuin family, SIRT1 has emerged as a key therapeutic target for aging-related liver diseases