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Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung

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This review summarizes the epidemiology of hereditary hemochromatosis and iron overload and discusses possible pathophysiologic mechanisms whereby iron excess can have toxic effects on cells.

To cross cell membranes, phosphorylated Vitamin B6 must be hydrolysed by alkaline phosphatase to free Vitamin B6. Transport into the cells is by simple diffusion followed by rephosphorylation

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