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The macromolecules that are the most polar are eluted last

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A study investigating the effect of folate and cobalamin deficiency during pregnancy found that deficiencies of these vitamins cause recurrent spontaneous abortion, preterm delivery, fetal malformations, low birth weight, stillbirth, and abruption of the placenta

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134 However, because of heterogeneity among cancer cells, other studies have shown that IDH2 expression is decreased in metastatic HCC and gastric cancer tissues compared with paired normal tissues