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Deeply conserved synteny and the evolution of metazoan chromosomes

In particular, under oxidative conditions, Nrf2 is released by its regulator Keap1, acquiring the ability to translocate in the nuclear compartment and to regulate the gene expression of the main antioxidant enzymes, deputed to the neutralization of superoxide and its derivates [106,107,108]

However, this needs further study

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65 This study also suggested that NF1 cNFs, which can occur in the 10s1000s in an individual patient, exhibit different critical molecular changes than sporadic NF1 +/+ cNFs, which generally occur in isolation