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Its essential to consider that, while IONPs have the ability to polarize macrophages towards an M1 phenotype in a tumor context, under certain circumstances, they can inhibit this inflammatory response by inducing polarization towards an M2 phenotype (167169)

Moreover, alterations in Ca 2+ flux mediated by MAM proteins due to MAM formation impede tumor and stromal cell mitochondrial metabolism within the tumor microenvironment

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10.1161/CIRCULATIONAHA.111.060368 152 Sharifi-RadMKumarN