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A major challenge is the wide heterogeneity in initial presentation and rates of progression, which is partly underpinned by variation in underlying pathological accumulations 2

The clinical and histological characteristics of the human samples are not publicly available due to data privacy, but that anonymized data can be obtained from the corresponding author J.G

Although a variety of secondary ligands can be used for this purpose, two of the most common are avidin and streptavidin for the adsorption of biotin-containing compounds and protein A or protein G for the adsorption of antibodies

Chavala, S

Without this ISC, its enzymatic activity is compromised