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1998 demonstrated statistically significant increases in IGF-I, GH pulse amplitude, and fat-free mass in a randomised, double-blind, placebo-controlled trial in healthy elderly subjects over two months

[DOI] [PubMed] [Google Scholar] 37.Kelly D, McFadyen M, King TP, Morgan PJ

Here, we report that mitochondrial-encoded MOTS-c can significantly enhance physical performance in young (2 mo.), middle-age (12 mo.), and old (22 mo.) mice

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