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& Peacock, S

Non-canonical independent defense systems In addition to the canonical GPX4/GSH axis, cells possess other parallel, GPX4-independent anti-ferroptotic pathways that provide additional layers of protection

Zahid M, Kohli E, Saeed M, Rogan E, Cavalieri E

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Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 1618