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Importantly, key phosphorylation sites at the 2 -AR include Ser345/346 (phosphorylated by PKA), Ser355/356/364/396/401/407/411, and T360 (phosphorylated by GRKs) in the C-tail and Ser261/262 (phosphorylated by PKA) in the third intracellular loop (Iyer et al., 2006
