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Rens EG, Merks RMH

In T cells of SLE patients, mTOR activation triggers ROS production, while SIRT2 concurrently upregulates IL-17A expression in these cells by modulating the mTOR complex 1 (mTORC1)/HIF-1/RORt signaling pathway, thereby contributing to the pathogenesis of SLE (101, 155)

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GOLM1 promotes epithelial-mesenchymal transition by activating TGF1/Smad2 signaling in prostate cancer

196 Besides, MSCs primed with BMP2 increase the level of IDO1, and the number of Foxp3 + CD25 + Tregs among CD4 + cells is further increased in ALI mice