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Escobar-Charry, M

Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation

5.2.1 AMPK activation and improvement of metabolic homeostasis: metformin Metformin primarily exerts its pharmacological effects by activating AMPK and suppressing hepatic gluconeogenesis, thereby restoring glucose metabolic homeostasis

The imprecision and inaccuracy in the predictiveness of diagnostic biochemical markers currently in use, makes pharmacological treatment more difficult 10

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On the other hand, it is advisable to promote MRD-driven dynamic treatment adjustmentspecifically, within hypomethylating agent plus venetoclax regimenswhere therapy intensity is individualized (escalated or de-escalated) based on serial MRD quantification (via multiparameter flow cytometry or sequencing)