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PMID: 21030672

An approved drug that inhibits NADH:ubiquinone oxidoreductase is the biguanide metformin 41 , the first-line treatment in type II diabetes 41

AGS was cultured in F-12 K medium (Boster) with 10% fetal bovine serum (Boster) , other cells were cultured in DMEM medium (Boster) with 10% fetal bovine serum (Boster) ,all cells under the condition of 5% CO and 37 C

Correspondingly, the inhibition of NF-B by BAY 11-7082 significantly increased the survived SGN numbers, while decreased the C-CASP3 positive SGN numbers and the C-CASP3 expression in peroxynitrite + BAY 11-7082 group compared with the peroxynitrite group (Figures 9DF)

In patients with Cirrhosis, a condition characterized by progressive damage to the liver, Glutathione has been shown to alleviate the severity of symptoms and enhance overall liver function

H 2 0 2 500 mol L 1 , which was used as a positive control, was added 15 min prior cell analysis