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Matsuo H, Chiba T, Nagamori S, Nakayama A, et al

Forsythiaside a alleviated carbon tetrachloride-induced liver fibrosis by modulating gut microbiota composition to increase short-chain fatty acids and restoring bile acids metabolism disorder

Under hyperglycemic conditions, the polyol pathway serves as a principal contributor to elevated NAD + consumption and excessive NADH generation, thereby disrupting the cytosolic free NADH/NAD + ratio and subsequently damaging neural and vascular function [19, 27]

doi: 10.1038/s43018-024-00811-3

However, since the differences in total GSH conjugation activity catalyzed by these allelic variants are not higher than 30 %, the differences in inactivation of reactive intermediates by hGSTP1-1 are not likely to be a major factor in determining interindividual difference in susceptibility to adverse drug reactions induced by the drugs studied [34]

[17] reported the key enzymes responding to GSH degradation in E
