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Reported side effects of corticosteroids include: Hydroelectrolytic disorders: sodium retention, potassium loss, hypokalemic alkalosis, fluid retention, congestive heart failure in susceptible patients, hypertension Musculoskeletal: muscle weakness, myopathy, loss of muscle mass, aggravation of myasthenic symptoms in myasthenia gravis, osteoporosis, vertebral compression fractures, aseptic necrosis of the head of the femur and humerus, pathologic fracture of long bones, tendon rupture Dermatological: impaired wound healing, atrophy and thinning of the skin, fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, suppression of reactions to skin tests, allergic dermatitis, urticaria, and angioedema

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[DOI] [PMC free article] [PubMed] [Google Scholar] Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A, Maier B

To denature the proteins, 120 L of 8 M urea in 50 mM Tris-HCl (pH 8) was added

By optimizing the selection of acid-sensitive bonds and molecular design, combined with efficient synthesis and purification processes, we ensure the linker is stable under physiological conditions and efficiently cleaves under acidic environments

It is studied in vitro across collagen and extracellular-matrix synthesis, gene-expression modulation and angiogenesis