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Notably, the protective effects of irisin were abated by the administration of the SIRT1 inhibitor EX527 in vivo or by siRNA-mediated knockdown of SIRT1 in vitro

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It is thought that hormonal changes such as this hypocortisolism may result in symptoms of fatigue experienced by patients (255, 428, 429)

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Moyer CA, Rounds J, Hannum JW

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