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Seizure-European J Epilepsy

TrxR/Trx regulate glyceral dehyde-3-phosphate dehydrogenase (GAPDH) by altering the glycolytic pathway [39]

Xu X, Stambrook PJ

J Physiol (2000) 529(Pt 3):55364.10.1111/j.1469-7793.2000.00553.x 89 JouavilleLSPintonPBastianuttoCRutterGARizzutoR

These mechanical signals operate via organized actin cytoskeletal networks and mechanosensitive transcription factors, particularly the (Yes-associated protein/Transcriptional coactivator with PDZ-binding motif (YAP/TAZ) complex (329)

In tumor cells, PKM2 is present mainly as the low-activity dimeric form, which leads to increased accumulation of diverse glycolytic intermediates required for macromolecule biosynthesis and thus promotes cancer proliferation (Zhao et al., 2022)
