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Hyperinflammatory shock in children during COVID-19 pandemic

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Ageing Res Rev 14:4355

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First, under normal conditions, elevated HO1 expression attenuates oxidative stress to exert cytoprotective effects, and second, sustained HO1 upregulation releases ferrous iron to exacerbate oxidative stress, which leads to ROS accumulation through the Fenton reaction
While empirical research on AOD-9604 is in early stages, there have been almost no reported side effects, and the treatment has no downtime
