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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Potterf SB, Virador V, Wakamatsu K, et al

8-week-old mice were chosen to receive a single bolus tail vein injection of rAAV9-shHADHA or rAAV9-shNC at 1*10 12 vg/mouse

Autoimmune conditions are hypothesized to occur through exacerbation of the immunoregulatory deficiency

Deletion of Mat1a gene in mice promotes chronic SAMe reduction in the liver, that leads to hepatic hyperplasia at 3 months of age, intrahepatic fat accumulation, MASH and fibrosis at 8 months and, spontaneous HCC by 18 months of age [68,69,80,100]