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from an independent Chinese research group (PMID: 34827486) demonstrated that Dihexa rescued cognitive impairment in APP/PS1 Alzheimer's disease model mice via the PI3K/AKT signaling pathway, providing the first independent replication of cognitive enhancement effects

doi: 10.1016/j.celrep.2022.111724 [DOI] [PubMed] [Google Scholar] 35.Trinko R, Diaz DM, Foscue E, Thompson SL, Taylor JR, DiLeone RJ

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An invasive approach includes delivery of medication directly to the brain through injection/surgical implants or disruption of the tight endothelial junction of the BBB to facilitate drug penetration