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GI issues like constipation, diarrhea, abdominal pain, and reflux should be documented when present

John Blangero

As a result, dysregulation of CSK may lead to many diseases with different underlying molecular mechanisms

However, the majority of the studies that have identified either rapid or normal GET were performed during the interspersed period, while those performed during the emetic phase have shown a significant gastric emptying delay, which might be related to either the activation of HPA axis resulting in the release of CRF, which inhibits foregut motility, or activation of dorsal vagal complex (DVC), which inhibits gastric motility via the efferent vagal pathway

Klein BEK, Klein R, Lee KE, Gangnon RE

Its not permanent if its done with Hyaluronic Acid fillers, like Voluma or Lyft, or even if its done with more permanent fillers, like Sculptra or Radiesse