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View Source Signal transduction and targeted therapy Identification of glutamine as a potential therapeutic target in dry eye disease 2025 DOI: 10.1038/s41392-024-02119-1 PMID: 39837870 Chen X, Zhang C, Peng F, et al

1 Introduction 1.1 Bile acids: key immuno-metabolic signals sculpted by the gut microbiota Bile acids (BAs), beyond their traditional role in lipid digestion, are now recognized as pleiotropic signaling molecules crucial for metabolic and immune homeostasis (1, 2)

The weight loss with cagrilintide monotherapy was comparable to liraglutide 3.0 mg used as an active comparator

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Cellular senescence is due to telomere shortening (replicative senescence) and oxidative stress (stress-related senescence) with activation of p53 and p16 that lead to activation of p21 and cell cycle arrest, respectively [93, 94]

Chlorogenic acid induces 4T1 breast cancer tumors apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice