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MNAM has been shown in vitro to be a significant enhancer of energy expenditure as well as a regulator of glucose metabolism

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AOD9604 has also been shown to have shown effects on heart disease through fat reduction and weight loss directly reducing the risk of heart disease

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NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)

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