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Additionally, after IOPs treatment, the protein expression of PI3K-p85, p-Akt (ser473), and glucose transporter protein 4 (GLUT4) was upregulated, suggesting that the anti-hyperglycemic mechanism of IOPs may involve the activation of PI3K and Akt phosphorylation, and GLUT4 transport in diabetic mice (Wang et al., 2017)

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Resveratrol (from grapes and red wine) enhances mitochondrial function, reduces oxidative stress, and activates neuroprotective proteins like SIRT1 (Zhou J

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