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The enzymatic activity of a HIF-1 deubiquitinase should increase HIF-1 stabilization

Of note, GBM 2012.2 cells showed higher basal levels of aspartate compared to 1919 GBM cells, which could explain their sensitivity to the blockage of aspartate by combining sertraline and chloroquine treatment (Figure S4)

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Such an effect is often seen in mice

The use of hydrophobic matrices proved highly effective for the MALDI determination of hydrophobic peptides

doi: 10.3390/cimb47060464