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Tryptophan (Trp) is an essential amino acid ingested from the diet, and 95% of free Trp is catabolized through the kynurenine pathway and is involved in the regulation of immunity, neuronal function, and intestinal homeostasis

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[79] this is thought to involve increased catecholaminergic signaling and the induction of cocaine- and amphetamine-regulated transcript (CART), a hypothalamic neuropeptide involved the regulation of food intake