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The oral formulation's convenience advantage over injectable semaglutide would be even more pronounced in pediatric populations, potentially making orforglipron the preferred first-line pharmacological option for adolescent obesity if efficacy and safety data support its use

qtot 0.343 13 OG311 1 ful O13 13 -0.553 15.9994

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA: Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria

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They reduce the oxidative stress that triggers excess melanin production