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2, Supplementary Fig

Study selection Study inclusion criteria were as follows: patients diagnosed with IC/BPS, interventions included relevant treatments, comparisons were specified as control or placebo, outcomes were mean differences for individual symptoms (pain, frequency, urgency and nocturia) and structured questionnaires (ICPI, ICSI, PUF and FBV) using an RCT study design

This study was reviewed and approved by the local Ethics Committees and Institutional Review Boards, according to the local laws and regulations

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In aged mouse models, GHK administration improved cognitive function by targeting anti-inflammatory and epigenetic pathways

The two methods give different results