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Tirzepatide heart palpitations occur through three primary mechanisms: vagal nervous system modulation from GLP-1 receptor activation in cardiac tissue, intravascular volume contraction from rapid weight loss and reduced fluid retention, and electrolyte shifts

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Nutrients, 9(8), 866

Gou and colleagues also found that HAPH was positively correlated with age, metabolic syndrome, male sex, obesity, and hypoxemia