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Although a specific link to -cell function was not explored in these studies, it has been reported that macrophages are the primary source of IGF1 in pancreatic islets, and that these cells function to enhance insulin secretion from -cells (115)

Conversely, NS5A viral protein is able to induce GPx4 by PI3K/AKT/mTOR pathway activation, protecting HCV infected cells against lipid peroxidation [250]

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